SciencemedicinePublic Health
Young People Are Tripping on Benadryl—and It’s Always a Bad Time
There’s a troubling new ritual unfolding in bedrooms and on social media feeds, a dangerous dance with delirium that speaks to a deeper, more profound ache among young people today. They’re swallowing fistfuls of diphenhydramine—the common antihistamine found in Benadryl—not for allergies, but for the promise of a trip, a journey that veterans of the experience will tell you is almost universally a nightmare.We’re talking about doses of twelve, fifteen, even twenty-five pills at a time, a chemical onslaught that doesn’t usher in euphoria but a stark, terrifying break from reality. The hallucinations are not psychedelic and wondrous; they are literal and horrifying.Users report full, unwavering conversations with people who aren’t there, spiders crawling up walls that remain pristine to anyone else, and the haunting sensation of insects burrowing under their own skin. This isn’t recreation; it’s a self-inflicted psychosis, a temporary madness chased for reasons that, when you sit and talk with those who’ve been there, often trace back to a desperate need to feel *something*, anything, even if that something is pure terror, or a perverse way to claim a badge of survival in a world that feels increasingly chaotic and indifferent.The social media challenge aspect, the dares on TikTok and YouTube to ‘take a Benadryl and see what happens,’ adds a layer of performative despair, turning a deeply personal crisis into public spectacle for clicks. It’s a modern twist on an old, dangerous game—deliriants like diphenhydramine belong to the same class as datura and other toxic plants that have been used in shamanic rites and poisonings for centuries, substances historically treated with immense respect and fear, not as fodder for a viral trend.The physiological toll is severe: the drug aggressively blocks acetylcholine, a crucial neurotransmitter, leading to rapid heartbeat, severe dry mouth, blurred vision, urinary retention, and seizures, with the risk of fatal overdose hanging over every massive dose. What does it say about our moment that such a bleak and physically damaging experience is being commodified as entertainment for Gen Z? It speaks to a perfect storm of factors: the easy, over-the-counter availability of the drug, making it more accessible than illicit substances for a teenager; a deep-seated boredom or nihilism amplified by pandemic isolation; and a fundamental misunderstanding, propagated in online echo chambers, of what constitutes a ‘real’ drug experience.There’s no harm-reduction community around Benadryl tripping, no guide to a safe dosage because a safe recreational dosage doesn’t exist—only a sliding scale of potential organ damage and psychological trauma. When I listen to the stories of those who’ve tried it, a common thread is the aftermath, the lingering sense of unease and the ‘brain fog’ that persists for days, a haunting reminder of a journey they never truly wanted to take but felt compelled to by a combination of internal anguish and external pressure. This isn’t a story about a new drug fad; it’s a story about a generation’s cry for help, manifesting in the most dangerous and heartbreaking of ways, using a medicine cabinet staple to briefly escape a reality that, for them, has become too much to bear.
#featured
#Benadryl
#drug abuse
#youth health
#deliriants
#dangerous trends
#public health warning
#Gen Z